A research team led by City University of Hong Kong (CityU) has discovered a brain signalling molecule that can improve decision-making performance.

The research team is led by Professor Li Ying of the Department of Biomedical Sciences.

The ground-breaking discovery involves the role of astrocytes in the decision-making dysfunction caused by chronic pain. They found that L-lactate, an important energy substrate, can improve decision-making performance.

The discovery paves the way for effectively mitigating cognitive disorders caused by chronic pain. The correlation between chronic pain and brain functions is a core area of Professor Li’s work.

Astrocytes, star-shaped cells in the central nervous system, are well equipped to influence neuronal functions. The researchers found that L-lactate released by astrocytes are utilised by neurons to affect information flow and synchrony in the brain neural circuitry.

The clinical connection between pain and increases in levels of anxiety, depression and cognitive disorders such as impaired decision making has long been recognised. The published data from their research shows that impaired L-lactate release may be one of the factors in cognitive deficit in chronic visceral pain.

“The truly novel discovery of our studies is the role of L-lactate in neuronal activity plasticity and neuronal network synchrony in the brain,” said Professor Li.

Animal experiments show that an L-lactate infusion into the anterior cingulate cortex (ACC) in the brain increases the percentage of good decisions among normal rats by up to 48% and significantly relieves decision-making dysfunction in rats with chronic visceral pain.

“The findings reveal that L-lactate should no longer be considered simply an energy substrate for neurons, but rather an important signalling molecule that can regulate neuroplasticity and synchrony in the brain neural circuitry. In addition, using L-lactate infusion, optogenetic or chemical genetic technology to activate astrocytes in abnormal neural circuitry may help alleviate cognitive deficit caused by chronic pain,” he explained.

The article titled “Astrocytic L-Lactate Signalling Facilitates Amygdala-Anterior Cingulate Cortex Synchrony and Decision Making in Rats” was published recently in Cell Report, a prestigious international life sciences journal covering entire areas of molecular and cell biology.

“It is possible that there are pathological decision-making deficits in other disease conditions, such as brain injury, Parkinson’s disease, and Alzheimer's disease. The mechanism responsible for decision-making deficits in specific pathological conditions is an important but complicated area of research,” commented Professor Li.

“In the future, we will further study the effects of L-lactate on cognitive functions such as learning, memorising, decision making and perception of pain. By conducting experiments of ‘rat gambling task,’ we will investigate whether the activation of astrocytes can rescue the decision-making deficits in rats with Alzheimer's disease. We will also investigate the role of L-lactate in this process, and explore whether L-lactate generated by moderate physical activity can enter the cerebrum through the blood-brain barrier to improve cognitive functions,” he added.

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